UCSF分析に続き、たばこによる認知症頻度増加確認

たばこが認知症予防に役立つというのは昔の話になった。

下段に示した、今年1月のUCSF analysisの発表により、それまでのデータがたばこメーカーによりずいぶん汚れたデータものだったことがわかった。

これに次いでの発表

今回は2 pack/日の喫煙状態と認知症の関連が明らかに。

Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and
Vascular Dementia
Minna Rusanen; Miia Kivipelto; Charles P. Quesenberry Jr; Jufen Zhou;
Rachel A. Whitmer
Arch Intern Med Published online October 25, 2010.
doi:10.1001/archinternmed.2010.393
http://archinte.ama-assn.org/cgi/content/abstract/archinternmed.2010.393?etoc


多民族住民ベースコホート:21123名の医療システムメンバー(1978 ~ 1985)

フォローアップ23年平均で、5367名(25.5%)認知症診断(1136名のアルツハイマー病、血管性認知症
年齢、性、教育、人種、結婚状態、高血圧、高脂血症、BMI、心疾患、卒中、アルコール使用補正
非喫煙者比較で、2pack/day超の場合、認知症リスク増加(補正ハザード比[HR], 2.14; 95% CI, 1.65-2.78)、AD (adjusted HR, 2.57; 95% CI, 1.63-4.03)、 VaD (adjusted HR, 2.72; 95% CI, 1.20-6.18)


USA todayは、重度喫煙は、アルツハイマー病を157%引き上げると報道

マスコミさんたちは、いかなる対応とるか楽しみ・・・JTというスポンサーさんのため、無視を決め込むのだろうけど・・・Google news(たばこ


UCSF解析:
Journal of Alzheimer Disease Volume 19, Number 2, January 2010 Pages 465-480
Janine K. Cataldo, Judith J. Prochaska, Stanton A. Glantz
Cigarette Smoking is a Risk Factor for Alzheimer’s Disease: An Analysis Controlling for Tobacco Industry Affiliation


Abstract: To examine the relationship between smoking and Alzheimer’s disease (AD) after controlling for study design, quality, secular trend, and tobacco industry affiliation of the authors, electronic databases were searched; 43 individual studies met the inclusion criteria. For evidence of tobacco industry affiliation, http://legacy.library.ucsf.edu was searched. One fourth (11/43) of individual studies had tobacco-affiliated authors. Using random effects meta-analysis, 18 case control studies without tobacco industry affiliation yielded a non-significant pooled odds ratio of 0.91 (95% CI, 0.75-1.10), while 8 case control studies with tobacco industry affiliation yielded a significant pooled odds ratio of 0.86 (95% CI, 0.75-0.98) suggesting that smoking protects against AD. In contrast, 14 cohort studies without tobacco-industry affiliation yielded a significantly increased relative risk of AD of 1.45 (95% CI, 1.16-1.80) associated with smoking and the three cohort studies with tobacco industry affiliation yielded a non-significant pooled relative risk of 0.60 (95% CI 0.27-1.32). A multiple regression analysis showed that case-control studies tended to yield lower average risk estimates than cohort studies (by -0.27±0.15, P=0.075), lower risk estimates for studies done by authors affiliated with the tobacco industry (by -0.37±0.13, P=0.008), no effect of the quality of the journal in which the study was published (measured by impact factor, P=0.828), and increasing secular trend in risk estimates (0.031/year ±0.013, P=0.02). The average risk of AD for cohort studies without tobacco industry affiliation of average quality published in 2007 was estimated to be 1.72±0.19 (P<0.0005). The available data indicate that smoking is a significant risk factor for AD.

by internalmedicine | 2010-10-26 09:17 | 精神・認知  

<< Fidaxomicin:C. ... interactive Ris... >>