Watch List :アクトスの横紋筋融解症 他

うがってみれば、トヨタ・プリウスを彷彿とさせるアクトスたたきとも思えるが・・・まぁそれもしかたない

JAMA誌: アクトスを安易に使うな! 2011-02-09



とどめでもないが、さらに、アクトスの横紋融解のwatch list 入り

FDA Adds 13 Drugs to Watch List
http://www.medscape.com/viewarticle/737056


Adverse Event Reporting System (AERS)

Benzonatate (Tessalon, Pfizer) :Death from accidental ingestion in children

Dronedarone hydrochloride (Multaq, Sanofi-Aventis):Drug interaction with warfarin (increased anticoagulant effect)

Epoetin alfa (Epogen/Procrit, Amgen):Possible contamination with shards from glass vial

Gemcitabine hydrochloride (Gemzar, Lilly):Veno-occlusive liver disease

Lanreotide acetate (Somatuline Depot, Beaufour Ipsen) :Pancreatitis, hemorrhagic and necrotizing pancreatitis

Lanthanum carbonate (Fosrenol, Shire):Swallowing complications, gastrointestinal obstruction (attributed to tablet hardness)

Levetiracetam (Keppra, UCB Inc) :Stevens-Johnson's syndrome, toxic epidermal necrolysis

Lithium citrate (Eskalith and Lithobid, Noven):Brugada syndrome

Lopinavir/Ritonavir oral solution (Kaletra, Abbott):Serious adverse events in neonates

Immune globulin G intravenous (human) 5% liquid preparation (Octagam, Octapharma USA):Thromboembolic adverse events

Pioglitazone HCl (Actos, Takeda):Rhabdomyolysis

Ranolazine (Ranexa, Gilead):Drug interaction with statins (rhabdomyolysis)

Sodium oxybate (Xyrem, Jazz):Death




日本では、アクトスの体重増加・浮腫リスクはともかく、骨折リスク、膀胱癌、黄斑変性などの注意喚起不十分だったことからこのことも無視されるかもしれない。

by internalmedicine | 2011-02-09 12:57 | 糖尿病・肥満  

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