気管支拡張症の肺機能・肺循環系への影響:嚢胞状>円柱状

まぁ従来言われてたとおりだが、CTの形態計測による確認ということだろう。

HRCT score in bronchiectasis: Correlation with pulmonary function tests and pulmonary artery pressure
Annals of Thoracic Medicine Vol. 3. (3) 82-86
94名の気管支拡張患者(62名:嚢胞性、32名:円柱状)
平均年齢53.4±17.5(SD) 

嚢胞性気管支拡張の方が、円柱状より、肺活量(FVC %)、1秒率(FEV1%)は有意に低く、
DLCO %も低下( p < 0.01)

嚢胞性群のほうが、PaO2が低く、PaCO2も高い( P < 0.0001)

HRCTスコアはFEV1%と相関(r= -0.51)
HRCTスコアは唯に嚢胞群で低下( P =0.002)し、SPAPと相関する( r =0.23)。


包括的 HTCTスコア( 10.3±2.5)はSPAP≧ 40 mmHgと関連する( P =0.011)



カウント方法

Each of the above parameters were scored from 0 in absence of a lesion through 3 according to severity of disease, with the small airway disease scored as 0 if it was absent or 1 if it was present. A global score for each patient was calculated from these measures that reflected the radiological overall severity of the disease process and its associations, with a maximum possible score of 16. [15] A bulla was defined as a sharp demarcated area of emphysema measuring ≥1 cm in diameter and possessing a wall <1 mm in thickness. Emphysema was defined as (1) an area of low attenuation in comparison with continuous normal lung parenchyma, with vascular disruption and lacking a well-defined wall; or (2) an area of low attenuation possessing a wall less than 1 mm in thickness. Criteria for associated small airway abnormalities included small centrilobular opacities, tree-in-bud opacities, bronchiectasis, air trapping, and mosaic perfusion.


Cross-Sectional Analysis of the Chest and Abdominal Wall (Hardcover)
by Robert J. Wechsler (Author)

by internalmedicine | 2008-07-19 10:46 | 呼吸器系  

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