先天性ろ紙上リアルタイムPCR法:CMV感染症に対するスクリーニングは感度悪すぎて、不適
2010年 04月 14日
しかしながら、PCR法は、感度が低く、約2/3の先天性CMV感染を見逃すことがわかった
Dried Blood Spot Real-time Polymerase Chain Reaction Assays to Screen Newborns for Congenital Cytomegalovirus Infection
the National Institute on Deafness and Other Communication Disorders CMV and Hearing Multicenter Screening (CHIMES) Study
JAMA. 2010;303(14):1375-1382.
・single-primer DBS PCR identified congenital CMV infection
sensitivity 28.3% (95% CI, 17.4%-41.4%)
specificit 99.9% (95% CI, 99.9%-100%)
positive LR 803.7 (95% CI, 278.7-2317.9)
negative LR 0.7 (95% CI, 0.6-0.8)
positive predictive value 80.9% (95% CI, 58.1%-94.5%)
negative predictive value 99.6% (95% CI, 99.5%-99.7%)
・The 2-primer DBS PCR assay identified infants with congenital CMV infection with sensitivity 34.4% (95% CI, 18.6%-53.2%)
specificity 99.9% (95% CI, 99.9%-100.0%)
positive LR 3088.9 (95% CI, 410.8-23 226.7)
negative LR 0.7 (95% CI, 0.5-0.8)
positive predictive value 91.7% (95% CI, 61.5%-99.8%)
negative predictive value 99.8% (95% CI, 99.6%-99.9%)
by internalmedicine | 2010-04-14 08:38 | 感染症