長期ω３多価脂肪酸：発作性心房細動予防効果を示唆する電気生理的変化

chronic fish oil supplementation

ヒトの肺静脈や左房の電気生理学的な変化をもたらすか？


Effects of Chronic Omega-3 Polyunsaturated Fatty Acid Supplementation on Human Pulmonary Vein and Left Atrial Electrophysiology in Paroxysmal Atrial Fibrillation
the American Journal of Cardiology Volume 108, Issue 4 , Pages 531-535, 15 August 2011

肺静脈・左房有効不応期：effective refractory period (ERPs)、 PV conduction、肺静脈内開始のsusceptibility to AFを評価。

魚脂群は、
(1) longer left-sided (p = 0.002) ・ right-sided (p = 0.001) pulmonary venous ERPs
(2) less dispersion of pulmonary venous ERPs (left PVs p = 0.001, right PVs p = 0.07)
(3) longer left atrial ERPs (p = 0.02)
(4) no difference in pulmonary venous conduction
(5) lower incidence of AF initiated from PVs during ERP testing (77% vs 31%, p = 0.02)
(6) prolongation of mean AF cycle length (p = 0.009) and shortest AF cycle length in PVs (p = 0.04).

肺静脈・左房有効不応期延長をもたらし、肺静脈内の心房細動開始感受性低下させる可能性

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Circulating Long-Chain ω-3 Fatty Acids and Incidence of Congestive Heart Failure in Older Adults: The Cardiovascular Health Study
A Cohort Study
Ann Int Med. August 2, 2011 vol. 155 no. 3 160-170


ω３それぞれ及び総量とも、老人のうっ血性心不全の頻度低下と関連する