単球・血小板凝集：COPD及び急性悪化で亢進

単球・血小板凝集（Mo-P）


COPD患者では循環血中Mo-P凝固亢進(mean (SD) 25.3 (8.3)% vs 19.5 (4.0)%, p=0.01).
Mo-P凝集はさらに急性悪化で促進 (32.0 (11.0)% vs 25.5 (6.4)%, p=0.03).
血小板p-selectin発現、可溶性P-selectinは各群で差は認めない。

Increased platelet activation in patients with stable and acute exacerbation of COPD
John D Maclay, David A McAllister, Shonna Johnston, Jennifer Raftis, Catherine McGuinnes, Andrew Deans, David E Newby, Nicholas L Mills, William MacNee
Thorax 2011;66:769-774 Published Online First: 20 April 2011 doi:10.1136/thx.2010.157529




血小板・単球由来のmicroparticleは、凝固カスケードの際の、フィブリン産生促進に関連している。
A: Microparticles derived from monocytes and bearing PSGL-1 and tissue factor will bind to microparticles derived from platelets or endothelial cells expressing P-selectin. Such microparticles aggregates will induce the generation of fibrin.
B: Microparticles derived from monocytes and bearing PSGL-1 and tissue factor will bind to activated platelets present at a site of vascular injury or inflammation and induce the generation of fibrin.