Severity of Asthma Scale:SOA アウトカム予測要素として単独ツールとして強力

喘息重症度尺度(Severity of Asthma Scale:SOA)

Asthma Control Test (ACT)、　FEV1、 Work Productivity and Impairment Index (WPAI)との比較

SOAスコアは臨床的アウトカムの最も強力な予測要素
logistic regression AUC values for the SOA score は、計画外受診で、最小　0.68 、最大で SAE急性増悪　0.77
CART analysisにて、SOAは持続的に重要な因子で、steroid burstの２６％最小要素、SAE急性増悪の 64%の最大要素
特定のエンドポイントにとって、SOAスコアはstand-aloneの予測因子であるが、他は組み合わせでアウトカム要素となり得る。

Severity of Asthma Score Predicts Clinical Outcomes in Patients With Moderate to Severe Persistent Asthma
Published online before print September 1, 2011, doi: 10.1378/chest.11-0020 CHEST January 2012 vol. 141 no. 1 58-65

Severity of Asthma Score Prospectively Predicts Clinical Outcomes
doi: 10.1378/chest.9792Chest October 2010 vol. 138 no. 4 supp 823A
Asthma Severity Tuesday, November 2, 2010


An Epidemiologic Study of Xolair (Omalizumab): Evaluating Clinical Effectiveness and Long-Term Safety in Patients With Moderate to Severe Asthma (EXCELS)
http://clinicaltrials.gov/show/NCT00252135

TENOR Study Group(2006) TENOR risk score predicts healthcare in adults with severe or difficult-to-treat asthma. Eur Respir J 28(6):1145–1155.

National Asthma Education and Prevention Program (2007) Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma (US Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD).

(2000) Validity of symptom and clinical measures of asthma severity for primary outpatient assessment of adult asthma. Br J Gen Pract 50(450):7–12.

(2007) Association of control and risk of severe asthma-related events in severe or difficult-to-treat asthma patients. Allergy 62(6):655–660.

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SOA: Items and Scoring

No. 1 Symptomes during past 2 wk? (choose only one) 0-4
None (0). Minimal (1), Occasional (2), Most days or nights (3), Every day or night (4)

Systemic corticosteroid use? (choose one or more)
No. 2 Ever used (0 or 2)
No. 3 Used in ther past y (0 or 2)
No. 4 Used ≧ 3 mo tithin past 2 y (0 or 3)

Other asthma medication use during past 2 wk?
No. 5 Inhaled β-agonists (SABA/LABA)   (none, < 2, ≥ 2 puffs/d) (0, 1, or 2)
No. 6 ICS by MDI (none, < 20, ≥ 20 puffs/d) (0, 1, or 2)
No. 7 Cromolyn/nedocromil (0 or 1)
No. 8 Anticholinergic therapy (0 or 1)
No. 9 Theophylline, oral β-agonist, or leukotriene modifier (0 or 1)
No. 10 Antihistamine, decongestant, or nasal spray (0 or 1)
No. 11  Home nebulizer use (0 or 1)
No. 12 Ever hospitalized for asthma? (no or yes) (0 or 1)
No. 13 Ever intubated for asthma? (no or yes) (0 or 1)