心血管合併症とCPAP療法


--長期的な心血管合併・死亡リスク減少  
Long-term Effects of Nasal Continuous Positive Airway Pressure Therapy on Cardiovascular Outcomes in Sleep Apnea Syndrome [[(Chest. 2005;127:2076-2084.):http://www.chestjournal.org/cgi/content/abstract/127/6/2076]]
CPAP-治療患者は非治療患者に比べAHI中央値低い(48.3 [interquartile range (IQR), 33.6 to 66.4] vs 36.7 [IQR, 27.4 to 55], respectively; p = 0.02)が、年齢、BMI、診断からの経過時間は同等であった。心血管疾患による死亡はCPAP治療より未治療にて非常に多い(14.8% vs 1.9%, respectively; p = 0.009 [log rank test])が、新規発生高血圧、心疾患、卒中に相違はなかった。総心血管イベント(死亡、新規心血管疾患の両者)はCPAP治療群より未治療群で多い(31% vs 18%, respectively; p < 0.05).


--[[C-Flex deviceとやらが有効   Chest. 2005;127:2085-2093:http://www.chestjournal.org/cgi/content/abstract/127/6/2085]]
---(CPAP talkから) [[Select Respironics’ REMstar® devices incorporate our patented C-Flex technology. C-Flex addresses one of the main obstacles to patient compliance: pressure intolerance. C-Flex lowers the pressure level at the beginning of exhalation, returning to set pressure before exhalation ends. The amount of pressure relief is based on the patient’s expiratory flow. Patients may select their preferred pressure level from a C-Flex setting of 1, 2 or 3. Using the triggering and cycling algorithms of Digital Auto-Trak™, C-Flex devices are able to respond on a breath-by-breath basis. C-Flex makes CPAP therapy more comfortable for users.:http://www.cpaptalk.com/viewArticle/Respironics-Remstar-Auto-Pro-2-C-Flex-Interview.html]]
---[[without C-Flex:http://www.cpap.com/downloadVideo.php?VGID=14]]
---[[with C-Flex:http://www.cpap.com/downloadVideo.php?VGID=15]]
---[[Respironics C-Flex Webpage:http://www.respironicsremstar.com/cflex.htm]]


--帝人は来年やっと記録型auto-CPAP導入とのこと・・・ビジネスパートナー選択の失敗という私の感想

by internalmedicine | 2005-06-10 16:53 | 呼吸器系  

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