Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including neuropeptides, cytoskeletal proteins, proteins from smooth muscle, cardiac muscle, liver, platelets and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC


Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
J. Clin. Invest. 118(8): 2796-2807 (2008). doi:10.1172/JCI34254.

Calpains are calcium-dependent enzymes that determine the fate of proteins through regulated proteolytic activity. Calpains have been linked to the modulation of memory and are key to the pathogenesis of Alzheimer disease (AD).

Cysteine protease inhibitorであるE64、さらなる抑制剤BDA-410 により、海馬でのニューロン機能保存が示された

by internalmedicine | 2008-08-08 10:46 | 精神・認知  

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