咳嗽とQOL

結論として、”呼吸器疾患の種類にかかわらず、疾患横断的に、咳は健康状態と逆相関を示す。
LCQとCQLQともに咳嗽の程度に関して追加情報をもたらす点で 重要である”ということ

ただ、属性に関して疾患毎の違いがありそうである・・・慢性咳嗽の心理的側面、


Impact of Cough Across Different Chronic Respiratory Diseases
Comparison of Two Cough-Specific Health-Related Quality of Life Questionnaires
(Chest. 2008; 134:295-302)

２つの咳特異的HRQoLのスコアの横断的比較

・Leicester Cough Questionnaire (LCQ)
・Cough Quality of Life Questionnaire (CQLQ)

＋一般的HRQoL測定である、EuroQolも施行

１４７名（慢性咳嗽 83名、COPD　18名、喘息 20名、気管支拡張 26名）

【結果】２群間でLCQとCOLQの有意な差なし(p = 0.24 and p = 0.26, respectively)

アンケートの属性毎の検討解析は4群間の心理的問題・機能的障害の違いが見いだされた (p = 0.01 and p = 0.05, respectively)

COLQスコアは、慢性咳嗽者において、心理的問題が気管支拡張患者より多く (p = 0.03) 、COPD患者より機能障害が少ない(p=0.04)ことを示唆する。

4疾患群全てで、一般健康状態に有意差がある(p = 0.04)。


CQLQとLCQの有意な逆相関が見られた(慢性咳嗽 r = – 0.56, p < 0.001; COPD r = – 0.49, p = 0.04; 喘息 r = – 0.94, p < 0.001; 気管支拡張 r = – 0.88, p < 0.001)。

EuroQol　VASにおける有意な相関がCOPD患者では認められる (r = 0.639, p = 0.004) が、咳アンケートスコアとFEV1の関連は認められない

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Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ) ：Thorax 2003;58:339-343（full free pdf）

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CSQoL
Evaluation of a Cough-Specific Quality-of-Life Questionnaire
(Chest. 2002;121:1123-1131.)

1　Family and or close friends can’t tolerate it anymore.
2　I have experienced prolonged absences from important activities such as work, school, or volunteer services.
3　I have been completely prevented from engaging in important activities such as work, school, or volunteer services.
4　I have lost my appetite.
5　I am sick to my stomach and vomit.
6　I cough and it makes me retch (dry heaves).
7　I have a fear that I might have AIDS or tuberculosis.
8　I have headaches.
9　I am concerned that I have cancer.
10　I am dizzy.
11　I wet my pants.
12　I soil my pants.
13　I sweat.
14　I am hoarse.
15　It hurts when I breathe.
16　I broke a rib.
17　I cannot sleep at night.
18　I have difficulty speaking on the phone.
19　I can no longer sing, for instance, in church.
20　I have stopped going to social activities such as movies, plays, and town meetings.
21　I have had to change my lifestyle.
22　I ache all over.
23　I am exhausted.
24　I am embarrassed.
25　I am upset by people thinking that I have something wrong with me.
26　I want to be reassured that I do not have anything seriously the matter with me.
27　I am self-conscious.
28　I am concerned that I have something seriously the matter with me.

日本版EuroQolについて：<pdf>