・Roche Holding AGが確認
Swine flu 'shows drug resistance'
Experts have reported the first case of swine flu that is resistant to tamiflu - the main drug being used to fight the pandemic.
Page last updated at 16:15 GMT, Monday, 29 June 2009 17:15 UK

Roche Holding AG confirmed a patient with H1N1 influenza in Denmark showed resistance to the antiviral drug.

Drug-Resistant Flu Strain Turns Up in Denmark but Doesn’t Last Long
An executive of Roche, the Swiss maker of Tamiflu, held a telephone news conference to describe the progress of the Danish patient, who apparently developed the resistant strain while being protectively treated with a low Tamiflu dose because a close contact had the swine flu. Doctors switched treatment to a different but related drug, Relenza, and the patient recovered.

Severe Respiratory Disease Concurrent with the Circulation of H1N1 Influenza
June 29, 2009 (10.1056/NEJMoa0904023)

Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico
June 29, 2009 (10.1056/NEJMoa0904252)


死亡事例:レントゲン写真では、両側肺胞性陰影が両肺のベースに広がり、進行し融合的となっている。組織では、細気管支壁の壊死(上矢印)、好中球浸潤(真ん中矢印)、著明な硝子膜を伴うdiffuse alveolar damage(下矢印).

Historical Perspective — Emergence of Influenza A (H1N1) Viruses
June 29, 2009 (10.1056/NEJMra0904322)

The Persistent Legacy of the 1918 Influenza Virus June 29, 2009 (10.1056/NEJMp0904819)

Spread of a Novel Influenza A (H1N1) Virus via Global Airline Transportation June 29, 2009 (10.1056/NEJMc0904559)
International Air Transport Association (IATA)のデータを用いた分析で、5月29日までのデータ

Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus in Humans
June 29, 2009 (10.1056/NEJMc0904264
767名のインフルエンザシーズンで、迅速検査(QuickVue Influenza A+B (Quidel))は、RT-PCR分析のS-OIVの陽性例に対して20/39(感度51%、95%CI 35-67%)、RT-PCRのH1N1季節型インフルエンザ陽性に対して12/19(感度 63%、95%CI 39-81%)。RT-PCRのH3N2インフルエンザ陽性へは6/19(感度 31%;95% CI、14-57%)。RT-PCRに対する特異性は99%


Results of RT-PCR Analyses of 3066 Specimens, According to Influenza A Subtype.

by internalmedicine | 2009-06-30 09:50 | インフルエンザ  

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